Journal of Biometrics & Biostatistics

Karić Amela

Publications

• Research Article
  The Frequency of C677T Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism in Southern East Bosnian Population
  Author(s): Karić Amela, Terzić Rifet, Jerkić Zoran and Mustedanagić-Mujanović JasminkaKarić Amela, Terzić Rifet, Jerkić Zoran and Mustedanagić-Mujanović Jasminka
  
  The C677T MTHFR polymorphism is distributed widely among ethnics populations and showing a high heterogeneity. The fact that there were no published data on the prevalence of C677T MTHFR polymorphism in Bosnia and Herzegovina prompted us to determine its prevalence in sample of Bosnian population. Two hundred and seven unrelated, apparently healthy subjects from Southern east Bosnia were included in study. Genotyping of C677T MTHFR polymorphism was done using polymerase chain reaction (PCR) followed by restriction digestion (RFLP) with HinfI enzyme. Out of 207 healthy subjects, 44.44% were heterozygous and 11.11% were homozygous for C677T MTHFR polymorphism. Allele and genotype frequency of MTHFR C677T did not differ between males and females carriers (X2=0.87; df=1; P=0.350).This study is the first to report frequency of C677T polymorphism in healthy Bosnian populatio.. Read More»
  DOI: 10.4172/2155-6180.1000169

  Abstract PDF