Journal of Dermatology and Dermatologic Diseases

Katsambas A

Publications

• Review Article
  Vitiligo, Melanoma Associated Hypopigmentation and Melanoma Incidence and Prognosis: Is There An Association?
  Author(s): Soura E and Katsambas ASoura E and Katsambas A
  
  Malignant melanoma is considered as the most lethal of all skin cancers. However, it is also one of the most immunogenic, characterized by specific antigen presentation and dense lymphocytic infiltration. Many studies concerning melanoma have reported the concurrent presence of vitiligo or Melanoma Associated Hypopigmentation (MAH). This type of vitiligo can appear before or after MM diagnosis, or in tandem with treatment with immunotherapeutic drugs and has been associated with an improved prognosis and/or better response to immunotherapy treatments. This may be attributed to the fact that activated T cells against antigens found on malignant melanocytes can also recognize normal melanocytes and destroy them. On the other side, very limited data exist on whether classic vitiligo can offer protection against or is associated with a decreased incidence of MM. However, MAH represents an.. Read More»
  DOI: 10.4172/2376-0427.1000213

  Abstract PDF