Environmental & Analytical Toxicology

Kawu MU

Publications

• Research Article
  Protective Effect of Vitamin C on Biochemical Alterations Induced by Subchronic Co-administration of Chlorpyrifos and Lead in Wistar Rats
  Author(s): Ambali SF, Angani M, Adole AO, Kawu MU, Shittu M, Akande MG and Oladipo OOAmbali SF, Angani M, Adole AO, Kawu MU, Shittu M, Akande MG and Oladipo OO
  
  Oxidative stress is one of the molecular mechanisms involved in chlorpyrifos (CPF) and lead poisoning. The present study investigated the role of vitamin C in mitigating the biochemical alterations induced by co-administration of CPF and lead. Forty adult male Wistar rats divided into 4 groups of 5 animals in each group were used for this study. Group I was dosed with corn oil (2 ml/kg) while group II was given vitamin C (100 mg/kg). Group III was co-administered CPF ( 4.25 mg/kg~ 1/20th LD50) and Pb (225 mg/kg~1/20th LD50) while group IV was pretreated with vitamin C (100 mg/kg) and then co-administered with CPF (4.25 mg/kg) and Pb (225 mg/kg), 30 min later. The regimens were administered once daily by oral gavage for a period of 9 weeks. The rats were sacrificed and sera obtained from the blood samples were analyzed for the total proteins, albumin, globulin, electrolytes (.. Read More»
  DOI: 10.4172/2161-0525.1000108

  Abstract PDF