Molecular and Genetic Medicine

Kazunori Sango

Publications

• Mini Review
  Physiological and Pathological Roles of Aldose Reductase in Schwann Cells
  Author(s): Kazunori Sango, Koichi Kato, Masami Tsukamoto, Naoko Niimi, Kazunori Utsunomiya and Kazuhiko WatabeKazunori Sango, Koichi Kato, Masami Tsukamoto, Naoko Niimi, Kazunori Utsunomiya and Kazuhiko Watabe
  
  Aldose reductase (AR), the first enzyme in the polyol pathway, is predominantly localized to Schwann cells in the peripheral nervous system (PNS). The exaggerated glucose flux into the pathway via AR in Schwann cells under diabetic conditions is thought to be a major contributing factor in the pathogenesis of diabetic neuropathy, and the restoring effects of AR inhibitors on the neurological symptoms of experimental diabetic animals and patients with diabetes have been investigated. In contrast, however, much less attention has been paid to the physiological functions of AR in the PNS and other tissues (i.e. osmoregulation, aldehyde detoxification, and steroid and catecholamine metabolism). In this paper, we focus on the functional significance of AR in Schwann cells under normal and diabetic conditions. A spontaneously immortalized adult mouse Schwann cell line IMS32 displays distinc.. Read More»
  

  Abstract PDF