London Breast Institute, The Princess Grace Hospital,
United Kingdom
Review Article
Management of Ductal Carcinoma In situ
Author(s): Kefah MokbelKefah Mokbel
Ductal carcinoma in situ (DCIS) is a heterogeneous disease characterized by noninvasive clonal proliferation of malignant epithelial cells arising from the mammary ducts and terminal ductal-lobular units. Its reported incidence is rising due to the wide adoption of screening mammography and magnetic resonance imaging (MRI). The combination of nuclear grade and presence of necrosis is currently the best predictor of biological behavior. DCIS should be managed in the context of a multidisciplinary team. Local control depends upon adequate surgical clearance with margins of at least 2mm. Sentinel lymph node biopsy (SLNB) is not routinely indicated and should be reserved for those with concurrent or recurrent invasive disease. SLNB can be considered in patients undergoing mastectomy (MX) and those with risk factors for invasion such as palpability, comedo morphology, necrosis or rec.. Read More»
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