Cardiovascular Diseases & Diagnosis

Keijiro Saku

Publications

• Research Article
  Comparison of 64Cu and 68Ga for Molecular Imaging of Atherosclerosis using the Apolipoprotein A-I Mimetic Peptide FAMP
  Author(s): Eiji Yahiro, Emi Kawachi, Shin-Ichiro Miura, Takashi Kuwano, Satoshi Imaizumi, Atsushi Iwata, Koki Hasegawa, Tsuneo Yano, Yasuyoshi Watanabe, Yoshinari Uehara and Keijiro SakuEiji Yahiro, Emi Kawachi, Shin-Ichiro Miura, Takashi Kuwano, Satoshi Imaizumi, Atsushi Iwata, Koki Hasegawa, Tsuneo Yano, Yasuyoshi Watanabe, Yoshinari Uehara and Keijiro Saku
  
  Background: Molecular imaging for detection of the atherosclerotic plaque burden has been highlighted as a modality for the diagnosis of atherosclerosis. We recently developed a novel and noninvasive positron emission tomography (PET) that was functionalized with an apolipoprotein (Apo) A-I mimetic peptide [known as Fukuoka University Apo A-I mimetic peptide (FAMP)] radiolabeled with gallium-68 (68Ga) - 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (DOTA) to specifically image the status of atherosclerotic plaque in myocardial infarctionprone Watanabe heritable hyperlipidemic rabbits (WHHL-MI). Methods and Results: To achieve more sensitive molecular imaging, FAMP was modified with 4, 11 - bis (carboxymethyl) - 1, 4, 8, 11 - tetraazabicyclo (6.6.2) hexadecane (CB-TE2A) and radiolabeled with copper-64 (64Cu) for PET, and the ability of 64Cu-TE2A-FAMP to image plaque wa.. Read More»
  DOI: 10.4172/2329-9517.1000201

  Abstract PDF