Journal of AIDS & Clinical Research

Kennedy Otwombe

Publications

• Research Article
  Lamivudine Monotherapy as a Holding Strategy in HIV-Infected Children in South Africa
  Author(s): Erica Maxine Lazarus, Kennedy Otwombe, Lee Fairlie, Sanlie Untiedt, Avy Violari, Fatima Laher, Denise Evans and Leon LevinErica Maxine Lazarus, Kennedy Otwombe, Lee Fairlie, Sanlie Untiedt, Avy Violari, Fatima Laher, Denise Evans and Leon Levin
  
  Background: Treatment options for HIV-infected children failing combination antiretroviral therapy (ART) are limited. We describe lamivudine monotherapy (LM) as a holding strategy for ART-experienced virologically-failing children where a definitive suppressive regimen was not possible. Methods: A retrospective review of data collected until the end of July 2010 from four sites in Johannesburg, South Africa was performed. Inclusion criteria were age ≤16 years with documented HIV-1 infection and use of LM for at least three months. Results: Twenty three patients (52% female) were identified. Median age at LM was 8.02 years (IQR: 4.07–11.80). LM was initiated for intractable adherence issues in 20/23 children (87%) and for multi-drug resistance precluding construction of an active new regimen in 3/23 (13%). The median duration of LM was 6.13 months (IQR: 3.93&nd.. Read More»
  DOI: 10.4172/2155-6113.1000246

  Abstract PDF