Medicinal Chemistry

Kenneth F Bastow

Publications

• Research Article
  Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents
  Author(s): Kyoko Nakagawa-Goto, Kenneth F Bastow, Emika Ohkoshi, Susan L Morris-Natschke and Kuo-Hsiung LeeKyoko Nakagawa-Goto, Kenneth F Bastow, Emika Ohkoshi, Susan L Morris-Natschke and Kuo-Hsiung Lee
  
  Drug usefulnessis frequently obstructed by the incidence of the multidrug resistance (MDR) phenotype and severe adverse effects. Exploiting collateral sensitive(CS)agents (in this case also called MDR-selective agents), which selectively target only MDR cells, is an emerging and novel approach to overcome MDR in cancer treatment. In prior studies, we found that 4’-methyl-6,6,8-triethyldesmosdumotin B (4’-Me-TEDB, 2) is an MDR-selective synthetic flavonoid with significant in vitro anticancer activity against a MDR cell line (KB-Vin) but without activity against the parent cells (KB) as well as other non-MDR tumor cells. Our recent results suggest the absolute MDR-selectivity varies depending on the cell-line system. In order to explore this further and to better understand the critical pharmacophores, we have synthesized nine novel analogues of 2, which contain heteroaroma.. Read More»
  DOI: 10.4172/2161-0444.1000101

  Abstract PDF