Journal of Pediatric Neurology and Medicine

Kevin Shalayda

Publications

• Research Article
  Topiramate as Migraine Prophylaxis in Pediatric Patients: An Integrated Summary of Randomized Controlled Trials
  Author(s): Lisa Ford, Yingqi Shi, Kevin Shalayda and Prasarn ManitpisitkulLisa Ford, Yingqi Shi, Kevin Shalayda and Prasarn Manitpisitkul
  
  Background: An integrated analysis of five randomized, placebo-controlled studies in migraine prophylaxis was conducted to assess topiramate’s efficacy and safety in pediatric patients. Methods: Study 1, a pivotal study (50-, 100 mg/day; aged 12-17 years), Study 2 (flexibly-dosed 2-3 mg/kg/day; aged 6-15 years), and Studies 3, 4 and 5 [50-, 100-, 200 mg/day; aged ≥ 12 years)]. Results: Percent reduction in the average monthly migraine attack rate: Study 1: the 100 mg/day group improved versus placebo (72% versus 44%, p=0.0164); Study 2: topiramate was not significantly different from placebo (58% versus 48%); Studies 3, 4 and 5: positive trend in the 100 mg/day group versus placebo (75% versus 37%). ≥ 50% reduction responder rate: Study 1 - the 100 mg/day group improved versus placebo (83% versus 45%, [.. Read More»
  DOI: 10.4172/2472-100X.1000112

  Abstract PDF