Journal of Cytology & Histology

Khalil A Kamal

Publications

• Research Article
  Immunohistochemical Study of the Effect of Green Tea Extract on Methotrexate- Induced Oral Mucositis in Albino Rats
  Author(s): Al-Refai A Sultan, Al-Barazenchy H Ali and Khalil A KamalAl-Refai A Sultan, Al-Barazenchy H Ali and Khalil A Kamal
  
  Methotrexate (MTX) had been used for many years and complications usually encountered during treatment especially in cancer patients. The aim of the present study was to determine the preventive and early-stage anti cytotoxic effects of green tea on the histology of the rats cheek mucosa treated by high single dose of methotrexate. The study included 36 Albino rats. Twelve animals were used in the pilot study to find the maximum toxic dose, and the other twenty four were divided into four groups: vehicle treated control group, green tea extract treated control group (40 mg/kg/day), Methotrexate treated group (80 mg/kg), and methotrexate and green tea extract treated group. Cheek mucosa excision was then performed. Histopathological examination was performed with hematoxylin-eosin, PAS and Masson’s trichrome stains. Cell proliferation was examined using the Ki-67 antibody and ant.. Read More»
  DOI: 10.4172/2157-7099.1000227

  Abstract PDF