Japan
Case Report
Extraskeletal Myxoid Chondrosarcoma-like Features in Metastasizing Lung Adenocarcinoma: Unique Morphological Changes after Chemo-radiotherapy
Author(s): Susumu Matsukuma, Hiroaki Takeo, Kimiya Sato, Aoi Yamashiro and Kimi KatoSusumu Matsukuma, Hiroaki Takeo, Kimiya Sato, Aoi Yamashiro and Kimi Kato
Lung cancer closely resembling Extraskeletal Myxoid Chondrosarcoma (EMC), called “primary pulmonary myxoid sarcoma (PPMS),” is an extremely rare tumor. This report is presented here of a unique case showing EMC-like changes only in metastases from conventional lung adenocarcinoma in an 81-year-old man. After lung tumor resection and chemo-radiotherapy, he underwent the resection of right adrenal metastasis composed of carcinomatous and EMC-like components. There were multifocal transitions between these components. He was treated with additional chemo-radiotherapy for newly developed liver and brain metastases, but he died 3.3 years after the initial surgery. Autopsy revealed EMC-like tumors, with or without minute adenocarcinomatous components, extensively involving widespread organs. Reverse transcription-polymerase chain reaction did not detect EWSR1- CREB1 fusion in th.. Read More»
DOI:
10.4172/2157-7099.1000220
Journal of Cytology & Histology received 2476 citations as per Google Scholar report