Journal of Bioprocessing & Biotechniques

Kishore Kumar Gopalakrishnan

Publications

• Research Article
  Effect of Media Sterilization Time on Penicillin G Production and Precursor Utilization in Batch Fermentation
  Author(s): Kishore Kumar Gopalakrishnan and Swaminathan DetchanamurthyKishore Kumar Gopalakrishnan and Swaminathan Detchanamurthy
  
  Benzyl Penicillin (Penicillin G) is a secondary metabolite (Antibiotic) derived from Penicillium chrysogenum. Batch fermentation is widely used in the production of Penicillin G in laboratory scale and as well as in Industrial scale. The fermentation media for the production is sterilised at 121o C for 30 minutes as a usual practise in both scales of production. In our present study the production media used to produce Penicillin G was sterilized at various time intervals and the change in penicillin production along with the level of precursors utilized by the P. chrysogenum were analysed. The change in sterilization time varied the proportion of fermentation media converted from complex to simple. Studies were carried out in both shake flask level and also in laboratory scale fermenter (3 litres) with media containing PAA (Phenyl acetic acid) as .. Read More»
  DOI: 10.4172/2155-9821.1000105

  Abstract PDF