Molecular and Genetic Medicine

Koch CE

Publications

• Short Communication
  Consecutive Rhinovirus Infection of Epithelial Cells Alters Chrono- Inflammatory Expression Network
  Author(s): Weckmann M, Becker T, Pech M, Koch CE, Oster H and Kopp MVWeckmann M, Becker T, Pech M, Koch CE, Oster H and Kopp MV
  
  Introduction: Asthma exacerbations are associated with viral upper respiratory tract infections, and rhinovirus (RV) is the major cause of these virus-associated exacerbation. Circadian clocks regulate physiological rhythms via transcriptional networks. These networks contain several feedback mechanisms inducing complex tissue specific patterns of gene activation and repression that help to maintain and regulate important biological processes. For example, the neutrophil inflammation of the lung is gated by epithelial circadian oscillators. We hypothesized that recurrent, human rhinovirus infection (HRVI) of in in vitro cultured cells alter the circadian-gated inflammatory networks and imprint a methylation pattern similar to the network found in asthmatic patients. Results: We measured the methylation of clock and inflammatory genes in the .. Read More»
  DOI: 10.4172/1747-0862.1000282

  Abstract PDF