Journal of Cytology & Histology

Komolafe OA

Publications

• Research Article
  Effects of Four Herbal Plants on Kidney Histomorphology in STZ-induced Diabetic Wistar Rats
  Author(s): Komolafe OA, Ofusori DA, Adewole OS, Ajayi SA, Ijomone MM and Fakunle JBKomolafe OA, Ofusori DA, Adewole OS, Ajayi SA, Ijomone MM and Fakunle JB
  
  The aim of this study is to investigate the effect of four herbal extract and their efficacy on the histomorphometry of the kidney in STZ induced diabetic rats with a view to understanding their antidiabetic properties. Forty- two healthy adult Wistar rats (Rattus novergicus) with an average weight of 153.4 g were randomly divided into seven groups (n=6). STZ (65 mg/kg) dissolved in citrate buffer was administered intraperitoneally to animals in groups (B-G) while animals in group A received equivalent volume of citrate buffer. Plant extracts (100 mg/kg) were administered daily (orally) to animals in groups C-F and glimepiride (anti-diabetic drug) to animals in group G for fourteen days. After the expiration of the study the animals were sacrificed and the kidneys were excised, fixed in 10% formol saline for histology and morphometric analysis. The glomeruli of the diabetic group were.. Read More»
  DOI: 10.4172/2157-7099.1000210

  Abstract PDF