Journal of Computer Science & Systems Biology

Krishna Kumar Ojha

Publications

• Research Article
  ArchaeProfile: A Database of Archaea and their Origins of Replication
  Author(s): Krishna Kumar Ojha and Swati DKrishna Kumar Ojha and Swati D
  
  Archaea are single cell microorganisms having several unique characteristics which differentiate them from bacteria. One of the key features which make archaea distinct from bacteria is the replication process, which is very different and resembles that of the eukaryotes. In-vivo mapping of the ori site in Archae is a time consuming and tedious job due to complexity involved in the culture of archaeal colony, which puts challenges as well as opportunity to scientist to devise in-silico method to map the Ori site in archaeal genomes. Z-curve approach is a widely used insilico method to predict the Ori site in archaea, but it is not equally successful for all archaeal genomes. Several other parameters like copy number and location of the cdc6 gene, AT rich region with the presence of origin recognition boxes (ORB) provide a better estimate of the Ori site in archaea. The motivation behi.. Read More»
  DOI: 10.4172/jcsb.1000174

  Abstract PDF