Journal of AIDS & Clinical Research

Krista J Siefried

Publications

• Research Article
  Is the HIV Dementia Scale a Reliable Tool for Assessing HIV-related Neurocognitive Decline?
  Author(s): Grace M Lu, Bruce J Brew, Krista J Siefried, Brian Draper and Lucette A CysiqueGrace M Lu, Bruce J Brew, Krista J Siefried, Brian Draper and Lucette A Cysique
  
  Background: The HIV Dementia scale (HDS) has been recommended as a cross-sectional screen for HIVassociated neurocognitive disorder (HAND) but its longitudinal usefulness has not been optimally established. Method: 55 HIV+ participants underwent baseline and follow-up HDS screening after an average of 3.9 (SD=1.1) months. They had completed standard neuropsychological (NP) evaluations within the last 6-18 months to calculate a baseline HAND rate (49.1%) and gold standard cognitive change performance: 12.7% showed mild to moderate decline compared to normative standards for NP change; 80% confidence interval; 1-tailed, the rest of the sample was cognitively stable. After normalizing HDS raw-scores, standard regression-based change scores were developed to quantify HDS-based decline, which corrected for practice effect, regression towards the mean, and yielded individual predict.. Read More»
  DOI: 10.4172/2155-6113.1000269

  Abstract PDF