Journal of Metabolic Syndrome

Kristien J Ledeganck

Publications

• Research Article
  Predictors of Insulin Resistance in Obesity and Type 2 Diabetes Mellitus - The Role of Magnesium
  Author(s): Soetkin Milbouw, Julie Verhaegen, An Verrijken, Tom Schepens, Benedicte Y De Winter, Luc F Van Gaal, Kristien J Ledeganck and Christophe EM De BlockSoetkin Milbouw, Julie Verhaegen, An Verrijken, Tom Schepens, Benedicte Y De Winter, Luc F Van Gaal, Kristien J Ledeganck and Christophe EM De Block
  
  Objectives: Hypomagnesaemia and insulin resistance are two major clinical problems, with intertwining pathophysiology. We aimed to explore this association in obese patients and in non-insulin-treated patients with type 2 diabetes mellitus (T2DM). Methods: Subjects were recruited from the outpatient diabetes/obesity clinic of the Antwerp University Hospital. The population (N=2731) consists of 2 subject groups with different degrees of insulin resistance and insulin secretory potential: 1) overweight (Body Mass index (BMI) ≥ 25 kg/m² and <30 kg/m²) and obese (BMI ≥ 30 kg/m²) subjects, 2) adult T2DM patients. Hypomagnesaemia was defined as serum magnesium <1.7 mg/dl. Insulin resistance was estimated using the Homeostasis model assessment (HOMA-IR; cut-off point 2.82). Results: Hypomagnesaemi.. Read More»
  DOI: 10.4172/2167-0943.1000235

  Abstract PDF