Veterinary Science & Technology

Kristopher JL Irizarry

Publications

• Research Article
  Leveraging Naked Mole Rat (Heterocephalus glaber) Comparative Genomics to Identify Canine Genes Modulating Susceptibility to Tumorigenesis and Cancer Phenotypes
  Author(s): Kristopher JL Irizarry, Natalie, Randall Bryden, Joseph Bertone and Yvonne DrechslerKristopher JL Irizarry, Natalie, Randall Bryden, Joseph Bertone and Yvonne Drechsler
  
  We utilized a comparative genomics approach to analyze a core set of tumorigenesis orthologs among human, mouse, dog and naked mole rat. The analysis identified cancer orthologs that are both conserved and divergent between dog and the cancer resistant species naked mole rat. These tumorigenesis orthologous are associated with phenotypes that modulate cancer susceptibility, cardiac development, craniofacial development, brain development, skeletal development, and immune function, to name a few. This bioinformatics approach employed a variety of literature mining tools to further uncover relationships between the tumorigenesis orthologs. Together, these results shed light on the relationship between breed formations, breed associated morphological traits and breed associated susceptibility to tumorigenesis. These findings support the use of a comparative genomic analysis between speci.. Read More»
  DOI: 10.4172/2157-7579.1000322

  Abstract PDF