Cardiovascular Diseases & Diagnosis

Kristopher S Lyons

Publications

• Research Article
  Wavelet Analysis of Doppler Flow Velocity Waveforms from the Ocular Circulation Detects Abnormalities in Micro-vascular Function in Heart Failure
  Author(s): Kristopher S Lyons, Aaron McCann, Auleen Millar, Vivienne McClenaghan, Caroline Bleakley, Gary E McVeigh and Mark T HarbinsonKristopher S Lyons, Aaron McCann, Auleen Millar, Vivienne McClenaghan, Caroline Bleakley, Gary E McVeigh and Mark T Harbinson
  
  Aims: Many pathological processes may result in Heart Failure (HF), however, the final clinical phenotype appears to be common to all aetiologies. Microvascular abnormalities in HF have been demonstrated in a variety of vascular beds however the effect of HF on the retrobulbar circulation is not known. We employed a novel method of analysing blood flow velocity waveforms in order to quantify changes in the Doppler signal obtained from the retrobulbar arteries between HF patients and controls. FMD was also assessed. Methods and Results: 32 patients with systolic HF on maximal medical therapy and 10 age and sex-matched controls were studied. Doppler waveforms were obtained from the ophthalmic, central retinal and brachial artery in all subjects. Waveforms were analysed using a wavelet technique which expressed each waveform in constituent freq.. Read More»
  DOI: 10.4172/2329-9517.1000210

  Abstract PDF