Journal of Bioanalysis & Biomedicine

Kumari A

Publications

• Research Article
  Pharmacokinetics of Gentamicin and its Interaction with Paracetamol after i.v. Administration in Buffalo Calves (Bubalus bubalis)
  Author(s): Baxla S.L, Kumar M, Jayachandran C, Roy B.K and Kumari ABaxla S.L, Kumar M, Jayachandran C, Roy B.K and Kumari A
  
  The disposition kinetics was conducted in fi ve healthy female buffalo calves following single i.v dose (5mg/kg) of gentamicin alone and with paracetamol (40mg/kg,i.v.). The study revealed that the plasma concentrations of gentamicin were signi fi cantly higher when it was given with paracetamol as compared to alone between 0.042 to 0.333 hrs and at 24 hrs. Serum concentrations of gentamicin was detected for longer period (48 hrs) in urine in both groups of experimental animals. In case of urine drug attained its peak level at the same time interval (1.5 hrs) in both groups with the concentration of 83.42±3.14 �?¯�?�?­ g/ml after alone and 545.1±25.85 �?¯�?�?­ g/ml with paracetamol administration. The extrapolated zero time plasma concentrations during distribution phase (A) and theoretical zero time plasma concentrations (Cº.. Read More»
  DOI: 10.4172/1948-593X.1000024

  Abstract PDF