Journal of Biometrics & Biostatistics

Kyunghee K Song

Publications

• Research Article
  Statistical considerations of length bias for evaluating diagnostic tests in screening studies
  Author(s): Kyunghee K SongKyunghee K Song
  
  A diagnostic test in a screening study detects a clinical condition of interest in its asymptomatic stage. Evaluating the diagnostic test in a screening study is a challenging task since a diagnostic test is evaluated based on its analytical and clinical performance. In order to evaluate clinical performance of a diagnostic test in a screening study, it is crucial to investigate clinical outcome studies such as survival studies. Furthermore, there are important biases to be considered in a screening study. In this paper, statistical issues associated with screening studies are discussed, and statistical adjustment for screening-related bias, which is called length bias, is presented. Both Vardi’s bias-adjusted nonparametric maximum likelihood estimator and linear combination estimators have shown to adjust length bias successfully, and generate bias-adjusted survival curve close.. Read More»
  DOI: 10.4172/2155-6180.S2-001

  Abstract PDF