Journal of Bioengineering & Biomedical Science

Laeticia Nassif

Publications

• Research Article
  Enhanced in-Vivo Bone Formation by Bone Marrow Differentiated Mesenchymal Stem Cells Grown in Chitosan Scaffold
  Author(s): Laeticia Nassif, Abdo Jurjus, Jihad Nassar, Joseph Ghafari and Marwan El SabbanLaeticia Nassif, Abdo Jurjus, Jihad Nassar, Joseph Ghafari and Marwan El Sabban
  
  Objective: The aim of this study is to evaluate whether the differentiation of BMMSC to osteoblasts seeded in a biocompatible scaffold in vitro, would enhance bone formation in vivo over existing bone. Background: The use of bone marrow derived mesenchymal stem cells (BMMSC) with appropriate scaffolds in critical size defects and ectopic sites has been proven to be a valuable bone tissue engineering (BTE) technique that could potentially overcome the drawbacks of the current bone graft modalities, but the use of such techniques to grow bone over existing cortical bone has not been investigated yet. Materials and Methods: Autologous rabbit BMMSC grown in Chitosan scaffolds and pretreated with dexamethasone (Dx) were transplanted subperiosteally and bilaterally over the calvarial bone of syngeneic rabbits. Biopsies were analysed using radiograph.. Read More»
  DOI: 10.4172/2155-9538.1000106

  Abstract PDF