Journal of Bioanalysis & Biomedicine

Laëtitia Sonia Rodes

Publications

• Research Article
  Identification of Lactobacillus Fermentum Strains with Potential against Colorectal Cancer by Characterizing Short Chain Fatty Acids Production, Anti-Proliferative Activity and Survival in an Intestinal Fluid: In Vitro Analysis
  Author(s): Imen Kahouli, Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Laëtitia Sonia Rodes, Moulay A. Alaoui-Jamali and Satya PrakashImen Kahouli, Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Laëtitia Sonia Rodes, Moulay A. Alaoui-Jamali and Satya Prakash
  
  The use of probiotics as preventive agents in colorectal cancer (CRC), as widely suggested in many clinical and pre-clinical studies, was often linked to the potency of short chain fatty acids (SCFAs) in the gut. However, there remains an incomplete understanding of the fatty-acid-producing activity of certain probiotics and their cancer preventive potential. In the current study, L. fermentum strains were investigated for their potential use with CRC treatments. Using cell-free extracts, L. fermentum NCIMB -5221, - 2797, and -8829 were first compared based on their SCFAs production and anti-proliferative activity against Caco-2 colon cancer cells. The corresponding SCFAs synthetic formulations, similar to the ones produced by the bacteria, were prepared and compared with the latter to determine the role and efficacy of naturally produced SCFAs in inhibiting the prol.. Read More»
  

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