Journal of Bioanalysis & Biomedicine

Lais Silva Fernandes

Publications

• Special Issue Article
  Preclinical Toxicity Evaluation of Quassia amara Extract with Potential Antimycobacterial Activity
  Author(s): Vinicius P. Arantes, Guilherme L. Emerick, Lais Silva Fernandes, Ivan O. Pereira and Georgino H. DeOliveiraVinicius P. Arantes, Guilherme L. Emerick, Lais Silva Fernandes, Ivan O. Pereira and Georgino H. DeOliveira
  
  This study aimed to evaluate the oral acute and sub chronic toxicity of Quassia amara (Q. amara) extract. For the acute toxicity study, six male and six female rats received 2000 and 5000 mg/kg Q. amara extract. Rats were observed for 14 days; after sacrifice, liver, kidneys, lung, spleen and heart were submitted to macroscopic analysis. No death occurred and just the liver presented significant difference compared to the control group. For subchronic toxicity, eight groups of 6 male and 6 female rats received 200, 400 and 800 μg/mL of extract of Q. amara. Prothrombin time, bilirubin, urea, creatinine and gamma glutamyl transpeptidase (γ-GT), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were used as markers of renal and hepatobiliary function, respectively. The male showed a slight rise in serum bilirubin and creatinine and th.. Read More»
  DOI: 10.4172/1948-593X.S5-004

  Abstract PDF