Journal of AIDS & Clinical Research

Lamech M Mwapagha

Publications

• Research Article
  Genetic Polymorphisms of the CX3CR1 Gene Associated with HIV-1 Infections in Kenyan Population
  Author(s): Lamech M Mwapagha, Zipporah W Ng’ang’a, Shem P Mutuiri, Barbara B Miheso and Samoel A KhamadiLamech M Mwapagha, Zipporah W Ng’ang’a, Shem P Mutuiri, Barbara B Miheso and Samoel A Khamadi
  
  Introduction: Repeated exposure to Human Immunodeficiency Virus (HIV) does not always result in infection. Understanding the mechanisms that confer protection against progressive infection with HIV-1 may be useful in the development of appropriate interventions. The impact of CX3CR1 polymorphisms on human immunodeficiency virus type 1 (HIV-1) pathogenesis is controversial, with conflicting reports of their role in disease progression in HIV-1 infected individuals. The aim of this study is to characterize polymorphisms of the CX3CR1 co-receptor gene among HIV infected adults and infants in a Kenyan Population. Methods: Clinical samples were obtained from 200 HIV infected infants and 200 HIV infected adults and genotyped for the CX3CR1 gene 280M and 249I mutations. These were identified by PCR–RFLP analysis after amplification of a 588 base pair sequence of CX3CR1 gene. Results:.. Read More»
  DOI: 10.4172/2155-6113.1000712

  Abstract PDF