Medicinal Chemistry

Lansiaux A

Publications

• Research Article
  Synthesis and Antiproliferative Activity of 2-amino-4-Anilinoquinazoline Derivatives
  Author(s): Ravez S, Schifano-Faux N, Barczyk A, Arsenlis S, Castillo Aguilera O, Baldeyrou B, Lansiaux A, Six P, Goossens JF, Depreux P and Goossens LRavez S, Schifano-Faux N, Barczyk A, Arsenlis S, Castillo Aguilera O, Baldeyrou B, Lansiaux A, Six P, Goossens JF, Depreux P and Goossens L
  
  Recently, we have reported a series of 4-anilino-6,7-dimethoxyquinazolines as tyrosine kinase inhibitors with interesting in vitro IC50 values for the Epidermal Growth Factor Receptor (EGFR) and/or for the Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2). In this paper, we studied the impact of amino group in C-2 position of the quinazoline core on this series. The new synthesized compounds described herein were evaluated for both in vitro EGFR and VEGFR-2 kinase inhibition and antiproliferative activity in different cancer cell lines (PC3, HT29 and MCF7). 2-Aminoquinazolines substituted by a carbamic acid ester group present an interesting antiproliferative activity without tyrosine kinase inhibition. Thus, we drew the present study to explore the potential interaction of these molecules with the double-stranded DNA, the targe.. Read More»
  DOI: 10.4172/2161-0444.1000245

  Abstract PDF