Molecular Biomarkers & Diagnosis

Lars Holmberg

Publications

• Research Article
  MITF Expression in Cutaneous Malignant Melanoma
  Author(s): Margrét Agnarsdóttir, Fredrik Ponten, Hans Garmo, Gunnar Wagenius, Lorelei Mucci, Kristina Magnusson, Lars Holmberg and Sonja Eaker-FältMargrét Agnarsdóttir, Fredrik Ponten, Hans Garmo, Gunnar Wagenius, Lorelei Mucci, Kristina Magnusson, Lars Holmberg and Sonja Eaker-Fält
  
  The MITF protein has a central role in the differentiation and survival of melanocytes. The aim of the study was to investigate whether MITF can be employed as a prognostic marker in patients operated on for cutaneous malignant melanoma. A cohort study design, based on information collected from population-based registries, was employed. For included patients (n=264) tissue microarrays were stained with immunohistochemistry to study the protein expression of MITF in primary malignant melanoma tumors by estimating the fraction of positive tumor cells and the staining intensity. Most of the tumors (84%) expressed MITF in >25% of the tumor cells and for 87% of the tumors the staining intensity was strong. Tumors with cell fraction >75% had a better prognosis compared with those with <75% (HR 0.44, 95% CI: 0.20-1.0, P=0.05). Tumors with a strong staining intensity tended to have .. Read More»
  DOI: 10.4172/2155-9929.1000129

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