Hungary
Research Article
L-Arginine Pathway Metabolites Predict 6 Months Outcome after Acute Ischemic Stroke
Author(s): Peter Csecsei, Lajos Nagy, Sandor Keki, Laszlo Szapary, Zsolt Illes, Nelli Farkas and Tihamer MolnarPeter Csecsei, Lajos Nagy, Sandor Keki, Laszlo Szapary, Zsolt Illes, Nelli Farkas and Tihamer Molnar
Background: Increased levels of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are associated with endothelial dysfunction. Here, we analyzed the relationship between L-arginine pathway metabolites and functional outcome of ischemic stroke at discharge and 6 months follow-up.
Methods: Plasma concentration of L-arginine, ADMA, SDMA were investigated in 46 patients at post-stroke 24 h. Outcome measures were assessed by modified Rankin scale (mRS) at hospital discharge and 6 months follow-up. According to change in mRS score during the 6 months period, patients were divided into subgroups of improved, unchanged and worsened function. Predictive role of L-arginine pathway metabolites were explored in these outcome groups.
Results: Significant inverse correlations were .. Read More»
DOI:
10.4172/2376-0281.1000315
International Journal of Neurorehabilitation received 1078 citations as per Google Scholar report