Biosensors & Bioelectronics

Laura Segatori

Publications

• Research Article
  Sensitive Detection of TNT using Competition Assay on Quartz Crystal Microbalance
  Author(s): Jinghui Wang, Mohammed AlMakhaita, Sibani Lisa Biswal and Laura SegatoriJinghui Wang, Mohammed AlMakhaita, Sibani Lisa Biswal and Laura Segatori
  
  Currently available TNT sensors are characterized by high sensitivity, but low specificity, which limits the detection of TNT in dirty environments. We report here a TNT sensor designed to measure the displacement of a TNT-specific antibody by quartz crystal microbalance (QCM). This sensor combines high sensitivity of detection (0.1 ng/mL) with the ability to distinguish TNT from molecules with similar chemical properties. Particularly, the reliability of this method for the detection of TNT in dirty environments was investigated by using fertilizer solution and artificial seawater. Instead of measuring actual binding of TNT, the method described is based on the displacement of an anti-TNT antibody, which allows quantifying the concentration of TNT in solution with higher sensitivity. In addition, by utilizing the rate of antibody displacement, the detection time is significantly decr.. Read More»
  DOI: 10.4172/2155-6210.1000115

  Abstract PDF