Medicinal Chemistry

Lei Du

Publications

• Research Article
  Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and ¹³C-NMR
  Author(s): Zhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun and Tiemin SunZhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun and Tiemin Sun
  
  Dexlansoprazole is an outstandingproton pump inhibitors, which is a chiral sulfoxide. We firstly report determination of the absolute configuration (AC) of dexlansoprazole by the combination of experimental and calculated optical rotation (OR), electronic circular dichroism (ECD) and 13C-NMR. The high agreement between theoretical and experimental data illustrates that this method would be used to determine the absolute configuration of chiral sulfoxide. .. Read More»
  DOI: 10.4172/2161-0444.1000270

  Abstract PDF