Molecular Biomarkers & Diagnosis

León Monzón Kalet

Publications

• Research Article
  Measurement of Serum EGF Levels, a Methodological Approach: Learning What Means “Low-/High-Concentration of EGF In Serum”. Some Clinical Implications
  Author(s): Gonzalez-Perez Idania, Cáceres Lavernia Haslen Hassiul, Carr Pérez Adriana and León Monzón KaletGonzalez-Perez Idania, Cáceres Lavernia Haslen Hassiul, Carr Pérez Adriana and León Monzón Kalet
  
  Background: Although the contribution of platelets to the measured serum EGF levels was reported by Oka since 1983, the majority of reports in healthy donors or patients do not control clotting times during the collection of the sera. This results in a variation of the notified values, additionally to the one already caused by the functional EGF SNP of the gene, that modulates the expression of the molecule. Both issues -platelets and SNP- make the conventional stratification by absolute serum EGF levels not suitable. Within this study we evaluated serum EGF levels in a panel of 105 healthy Cuban donors, balanced by gender and age (from 18-78 years). As a result, a new stratification methodology for the comparison between individuals was proposed. Methods: The EGF was estimated in sera collected at two different clotting times: 1h an.. Read More»
  DOI: 10.4172/2155-9929.1000335

  Abstract PDF