Molecular and Genetic Medicine

Leon F A G Massuger

Publications

• Research Article
  Differential Associations of MMP-2 and MMP-14 with Stromal Amounts and T lymphocyte Presence in Ovarian Cancer
  Author(s): M Caroline Vos, Elise Bekers, Brenda L Den Oudsten, Ella de Boed, Anneke A M van der Wurff, Toin H van Kuppevelt, Katarina Wolf and Leon F A G MassugerM Caroline Vos, Elise Bekers, Brenda L Den Oudsten, Ella de Boed, Anneke A M van der Wurff, Toin H van Kuppevelt, Katarina Wolf and Leon F A G Massuger
  
  Aim: Ovarian cancer prognosis is influenced by factors such as intratumoral T-lymphocyte presence and the amount of stroma formation relative to the epithelial tumor compartment. The regulation of these factors is unknown. Matrix metalloproteinases are involved in stromal remodeling and may be involved in T-cell trafficking as well. This study investigates the quantitative relationships between the matrix metalloproteinases MMP-2 and MMP-14 and both relative stroma amounts (‘stroma percentage’) and the presence of T lymphocytes in the stromal and epithelial compartments of ovarian cancer. Patients and methods: In 86 patients with ovarian cancer, MMP-2 and MMP-14 expression and T-lymphocyte presence was determined using semi quantitative immunohistochemistry. Stroma percentage was determined by area calculation in haematoxylin eos.. Read More»
  

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