Molecular Biology: Open Access

Lesetja R. Motadi

Publications

• Research Article
  Anti-Proliferative Effects of the Methanolic Extract of Kedrostis Foetidissima in Breast Cancer Cell Lines
  Author(s): Mpho Choene and Lesetja R. MotadiMpho Choene and Lesetja R. Motadi
  
  Traditional plants have been a great source of medicine in developing countries, such as African countries, India and China. But in the 20th century, scientists in both developed and developing countries have been growing interest in medicinal plants due to their observed antibacterial and anti-proliferative properties. Accordingly, the study was aimed to investigate possible anti-proliferative effects of K. foetidissima that are associated with the potential anticarcinogenic properties in breast cancer. MCF-7 and YMB-1 cell lines were exposed to different concentrations (0-100 μg/ml) of the crude methanolic extract to evaluate their growth inhibitory and apoptosis inducing effects. The extract elicited a dose- and time-dependent inhibition of cell proliferation, followed by a concomitant decrease in cell viability. The observed cytotoxicity was linked to the .. Read More»
  DOI: 10.4172/2168-9547.1000107

  Abstract PDF