Journal of AIDS & Clinical Research

Leslie Hall

Publications

• Research Article
  Virological and Immunological Long-Term Outcome of Human Immunodeficiency Virus-1 Infected Children Treated before One Year and after Two Years of Age in a Resource-Limited Setting of South Africa
  Author(s): Jean-Christophe Beghin, Jean Ruelle, Patrick Goubau, Malini Krishna, Leslie Hall and Dimitri Van der LindenJean-Christophe Beghin, Jean Ruelle, Patrick Goubau, Malini Krishna, Leslie Hall and Dimitri Van der Linden
  
  Introduction: Benefits of early Highly Active AntiRetroviral Therapy (HAART) to reduce infant mortality and morbidity have been demonstrated in resource-limited and rich settings. However, immunovirological data collected in Sub-Saharan Africa are scarce. This study describes the long-term outcome of South African children who started HAART before one year of age (Early Starters Cohort or ESC) and compare their immunovirological outcomes to children who started their therapy after two years of age (Late Starters Cohort or LSC). Immunovirological results will be compared in order to evaluate the long-term non-inferiority of early treatment initiation. Methods: Fifty-five children were included in the ESC (mean follow-up period 7.9 years) and 96 children were included in the LSC (mean follow-up period 6.3 years). Children from the ESC and the LSC were subdivided into three subgroups ac.. Read More»
  DOI: 10.4172/2155-6113.1000690

  Abstract PDF