Cancer Science & Therapy

Lesly Ann Lopez-Skinner

Publications

• Research Article
  Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function
  Author(s): Amanda Gatesman Ammer, Laura C. Kelley, Karen E. Hayes, Jason V. Evans, Lesly Ann Lopez-Skinner, Karen H. Martin, Barbara Frederick, Brian L. Rothschild, David Raben, Paul Elvin, Tim P. Green and Scott A. WeedAmanda Gatesman Ammer, Laura C. Kelley, Karen E. Hayes, Jason V. Evans, Lesly Ann Lopez-Skinner, Karen H. Martin, Barbara Frederick, Brian L. Rothschild, David Raben, Paul Elvin, Tim P. Green and Scott A. Weed
  
  Elevated Src kinase activity is linked to the progression of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Src regulates HNSCC proliferation and tumor invasion, with the Src-targeted small molecule inhibitor saracatinib displaying potent anti-invasive effects in preclinical studies. However, the pro-invasive cellular mechanism(s) perturbed by saracatinib are unclear. The anti-proliferative and anti-invasive effects of saracatinib on HNSCC cell lines were therefore investigated in preclinical cell and mouse model systems. Saracatinib treatment inhibited growth, cell cycle progression and transwell Matrigel invasion in HNSCC cell lines. Dose-dependent decreases in Src activation and phosphorylation of the invasion-associated substrates focal adhesion kinase, p130 CAS and cortactin were also observed. While saracatinib did not significantly impact HNSCC tumor gro.. Read More»
  

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