Molecular Biomarkers & Diagnosis

Li Chen

Publications

• Research Article
  Aberrant Hypomethylated KRAS and RASGRF2 as a Candidate Biomarker of Low Level Benzene Hematotoxicity
  Author(s): Jing Yang, Wenlin Bai, Zhongxin Xiao, Yujiao Chen, Li Chen, Lefeng Zhang, Junxiang Ma, Lin Tian and Ai GaoJing Yang, Wenlin Bai, Zhongxin Xiao, Yujiao Chen, Li Chen, Lefeng Zhang, Junxiang Ma, Lin Tian and Ai Gao
  
  Benzene is an important industrial chemical and an environmental contaminant. The mechanisms of low level benzene-induced hematotoxicity are unresolved. Aberrant DNA methylation, which may lead to genomic instability and the altered gene expression, is frequently observed in hematological cancers. The purpose of the present study was to conduct a genome-wide investigation to examine comprehensively whether low level benzene induces DNA methylation alteration in the benzene-exposed workers. Infinium 450K methylation array was used to compare methylation levels of the low level benzene-exposed individuals and health controls and the differentially expressed DNA methylation pattern critical for benzene hematotoxicity were screened. Signal net analysis showed that two key hypomethylated KRAS and RASGRF2 associated with low level benzene exposure were identified. Further, the hypomethylate.. Read More»
  DOI: 10.4172/2155-9929.1000195

  Abstract PDF