Journal of Nephrology & Therapeutics

Lihua Li

Publications

• Research Article
  Effect of Personalized Dialysate Sodium Prescription on Plasma Sodium Concentration and Sodium Set Point in Conventional, Quotidian and Nocturnal Home Hemodialysis
  Author(s): Benjamin Thomson, Lihua Li and Robert LindsayBenjamin Thomson, Lihua Li and Robert Lindsay
  
  Introduction and objectives: In thrice weekly conventional hemodialysis, dialysate sodium prescription can cause intradialytic plasma sodium shifts, and undesirable symptoms. However, changes in pre-dialysis plasma sodium setpoint are not observed. Whether these clinical observations are observed in quotidian or nocturnal home hemodialysis has not been prospectively evaluated. Methods: A randomized crossover study of conventional, quotidian and nocturnal home hemodialysis patients was performed. Dialysate sodium was personalized 3 mmol/L above (HIGHDIALSOD) or below (LOWDialSOD) the SP, with 100 days for each crossover studies period. Results: Plasma Na+ decreased during hemodialysis in LOWDialSOD study period (136.8 to 135.0 mmol/L, p=0.002). Pre-Na+ SP (137.4 to 136.8 mmol/L, p=0.03) and Pre-Na+ SP slope (0.014 to -0.015 mmol/L/day, p=0.009) decreased from HIGHDialSOD to LOWDialSO.. Read More»
  DOI: 10.4172/2161-0959.1000294

  Abstract PDF