Molecular Biology: Open Access

Lin Wang

Publications

• Research Article
  Cytosolic Iron-Sulfur Protein Assembly 1 (CIAO1) Downstream Activation of Phospholipase A2 and Hormone-Mediated Signaling-Induced Cell Death Network in Human Hepatocellular Carcinoma (HCC) by Systems-Theoretical Analysis
  Author(s): Lianxiu Qi, Lin Wang, Minghu Jiang, Juxiang Huang and Hong LinLianxiu Qi, Lin Wang, Minghu Jiang, Juxiang Huang and Hong Lin
  
  We constructed the significant high expression (fold change ≥ 2) cytosolic iron-sulfur protein assembly 1 (CIAO1) downstream activation of phospholipase A2 and hormone-mediated signaling-induced cell death network in human Hepato Cellular Carcinoma (HCC), compared with low expression no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) in GEO data set, by using integration of gene regulatory activated and inhibited network inference method. Our result showed that CIAO1 downstream activation of phospholipase A2 and hormone-mediated signaling-induced cell death upstream network had no result, and downstream CIAO1-activated PLA2G1B, NUP62 in HCC. By integrative analysis of biological processes simultaneous occurrence between the different CIAO1 activated downstream cell death gene ontology (GO) network of HCC compared with CIAO1.. Read More»
  DOI: 10.4172/2168-9547.1000105

  Abstract PDF