Journal of Health & Medical Informatics

Lingyan Zhu

Publications

• Research Article
  Mechanisms of Detoxification and Anti-Oxidation of Nrf2 ARE Pathway in Isonicotinic Acid Hydrazide-Induced Mouse Liver Injury
  Author(s): Zhongrui Zhang, Lei Song, Lingyan Zhu, Shufeng Sun, Guoying Zheng, Qi Ren, Yonghong Xiao and Fumin FengZhongrui Zhang, Lei Song, Lingyan Zhu, Shufeng Sun, Guoying Zheng, Qi Ren, Yonghong Xiao and Fumin Feng
  
  The regulatory mechanisms of nuclear factor erythroid 2-related factor 2 (Nrf2) mainly include detoxification and antioxidation in the progress of isonicotinic acid hydrazide (INH)-induced liver injury. The interaction and protective effects of these two injury mechanisms have not been reported. In this study, eight Kunming mice were administered with INH via gavage at a dose of 90 mg/kg.d. The mice were then killed for 1 d, 3 d, 5 d, 7 d, 2 w, 3 w, and 4 w, and the control groups received gavage of the same volume of distilled water. The pathological changes of liver tissues and location of Nrf2 in liver cell were observed. The superoxide dismutase (SOD) and malondialdehyde (MDA), as well as the expressions of Nrf2, glutathione S-transferase (GST), and SOD mRNAs and proteins were examined. After drug administration for 1–2 weeks, the SOD (total SOD,.. Read More»
  DOI: 10.4172/2157-7420.1000221

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