Malaria Control & Elimination

Louis Koné Penali

Publications

• Research Article
  Sulfadoxine-Pyrimethamine Resistant Haplotypes in Asymptomatically and Symptomatically Malaria Infected Individuals in Côte d’Ivoire
  Author(s): Berenger Aristide Ako Ako, Marnie Johansson, Rokia Traore, Toure André Offianan, Eric Adji Gbessi, Coulibaly Mangoa Yahya, Simon-Pierre Assanvo Nguetta, Louis Koné Penali and Carol Hopkins SibleyBerenger Aristide Ako Ako, Marnie Johansson, Rokia Traore, Toure André Offianan, Eric Adji Gbessi, Coulibaly Mangoa Yahya, Simon-Pierre Assanvo Nguetta, Louis Koné Penali and Carol Hopkins Sibley
  
  Background: Most studies that assess efficacy of antimalarial drugs focus on the outcome of clinical treatment. However, community surveys of surrogate indicators are often more practical and can provide a wider view of possible changes in drug response, but it has not been clear whether assessment of parasite isolates from patients and asymptomatic individuals are directly comparable. In the present work, we have compared the prevalence of molecular markers associated with resistance to sulfadoxine-pyrimethamine in parasites isolated from asymptomatic and symptomatic individuals. Methods: The study was conducted during April and May 2008 in Anonkoua-Kouté (Abobo-Abidjan) in southern Côte d’Ivoire, an area where SP has been intensively used for more than 20 years. Plasmodium falciparum monospecific infection was detected by blood smears, followed by a genomic DNA extra.. Read More»
  

  Abstract PDF