Molecular Biomarkers & Diagnosis

Lugenia Rochelle

Publications

• Research Article
  Crisprs/Cas9 May Provide New Method for Drug Discovery and Development
  Author(s): Zhabiz Golkar, Lugenia Rochelle and Omar BagasraZhabiz Golkar, Lugenia Rochelle and Omar Bagasra
  
  The CRISPR/Cas9 (Clustered Regions of Interspersed Palindromic Repeats-Cas9, consists of a DNA-nuclease and a piece of RNA that homes in on a DNA sequence, enabling investigators to create precisely targeted mutations, corrections to mutations, or other gene modulation. CRISPR/Cas9 is an ancient anti-viral immune system found in bacteria and archaea. The immediate assumption would be that it is a primitive innate immune system like a restriction enzyme defense system known since 1970 and is the backbone of the gene cloning methods Surprisingly, it is a sophisticated adaptive immune system very different from the somatic gene recombination, which is wellknown and is found in higher vertebrate animals as T and B lymphocytes. This amazing newly discovered CRISPR has emerged as a magnum opus of programmable nuclease technology for the precise editing of the ge.. Read More»
  DOI: 10.4172/2155-9929.1000280

  Abstract PDF