Journal of Bioanalysis & Biomedicine

Luguang Luo

Publications

• Editorial
  The Biochemical Cascades of the Human Pancreatic β-Cells: The Role of MicroRNAs
  Author(s): Joseph W Kim, John Z Luo and Luguang LuoJoseph W Kim, John Z Luo and Luguang Luo
  
  Diabetes mellitus is a disease that poses a burden to the health care system due to its prevalence and chronic nature. Understanding β cell pathophysiology may lead to future therapeutic options for diabetes mellitus type 1 and 2. MicroRNAs (MiR) fine-tune β cell biochemical cascades through specific protein targets. This review argues that miRs may play a critical role in human islet β cell biology and are potential candidates for a new pharmacological strategy. We have reviewed and presented how miRs fine tune four biochemical cascades in islet β cells: glucose stimulated insulin secretion, β cell replication, apoptosis, and development. Only studies that examine human pancreatic islets either in vitro or in vivo are included. The unveiling role of miR pathways in regulating human islet β cell biology could open the door for diagnostic and therapeutic m.. Read More»
  DOI: 10.4172/1948-593X.1000e133

  Abstract PDF