Journal of Cytology & Histology

Luigi Vaccarella

Publications

• Research Article
  Does Exist A Correlation Between BMI and Gleason Patterns 4 and 5 At Prostate Biopsy?
  Author(s): Vincenzo Serretta, Giovanni Caruana, Francesco Sommatino, Salvatore Scurria, Giuseppe Carità, Luigi Vaccarella, Federico Torretta, Giuseppe Cicero, Marcello Daricello and Vito FrancoVincenzo Serretta, Giovanni Caruana, Francesco Sommatino, Salvatore Scurria, Giuseppe Carità, Luigi Vaccarella, Federico Torretta, Giuseppe Cicero, Marcello Daricello and Vito Franco
  
  Background: Obesity has been related with higher Gleason grade and worse prognosis. Increasing proportion of Gleason pattern 4 or 5 is a critical factor for biochemical recurrence, progression and mortality. The endocrine activity of visceral fat could be responsible of the differentation of the prostatic malignant cell towards a more aggressive fenotype. The aim of our study was to correlate Body Mass Index with the presence of Gleason pattern 4 or higher at biopsy. Materials and Methods: Consecutive patients with positive prostate biopsy were included. A transrectal prostate biopsy procedure with 12 cores, was performed. All tissue samples were reviewed. Results: Out of 135 patients diagnosed with prostate cancer at biopsy, a Gleason. pattern 4 or 5 was evident in 57 (42%) patients, while it was not detected in 78 (58%). The statistical analysis did no.. Read More»
  DOI: 10.4172/2157-7099.1000182

  Abstract PDF