Journal of Hypertension: Open Access

Luis I Juncos

Publications

• Review Article
  Dual Blocking of the Renin Angiotensin System: A Settled Issue?
  Author(s): Luis I Juncos and Caputo JoaquinLuis I Juncos and Caputo Joaquin
  
  The renin-angiotensin system (RAS) exerts wide-ranging effects on cardiovascular and kidney function. Oddly, this system that was designed to preserve normal hemodynamics may become harmful in certain clinical situations. For this reason, RAS inhibition is a highly effective therapeutic approach, not only to lower blood pressure but also to reduce kidney and cardiovascular disease morbidity and mortality. In some patients however, these beneficial effects of RAS inhibition are incomplete or absent. For these less than ideal results, several reasons have been proposed; e.g.: angiotensin escape, over production of angiotensin from negative feedback, local tissue RAS, etc. To secure better RAS blocking, some clinicians have proposed increasing the dose of angiotensin converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB’s) beyond the recommended doses or comb.. Read More»
  DOI: 10.4172/2167-1095.1000148

  Abstract PDF