Journal of Bioanalysis & Biomedicine

Luiz Alberto Lira Soares

Publications

• Research Article
  Comparative Bioavailability of a Generic and Two Compounded Naproxen Sodium Suspensions Administered to Rats
  Author(s): Lílian Grace da Silva Solon, Gerlane Bernardo Coelho Guerra, Aurigena Antunes de Araújo, José Mário Barichello, José Pérez-Urizar and Luiz Alberto Lira SoaresLílian Grace da Silva Solon, Gerlane Bernardo Coelho Guerra, Aurigena Antunes de Araújo, José Mário Barichello, José Pérez-Urizar and Luiz Alberto Lira Soares
  
  The purpose of this study was to determine naproxen concentrations in rat plasma samples by HPLC and to compare the bioavailability of a generic and two compounded naproxen sodium suspensions (test 1 and test 2). Analysis was run at a fl ow rate of 1.2 mL.min-1 with a mobile phase of acetonitrile: NaH2PO4 0.01 M pH 4.00 (50:50, v/v) at 280 nm, using a C18 column (150 mm x 4.6 mm, 5 μm). The calibration curve was linear (R2 = 0.9987) over the range of 0.25 - 200 μg.mL-1. The precision for inter and intra-day analysis ranged from 2.46% to 12.39%. Cmax, Tmax and AUCt were 191.25 ± 11.17 μg.mL-1, 1.00 ± 0.106 h and 2438.16 ± 291.34 μg.h.mL-1 for the reference drug, 188.22 ± 24.78 μg.mL-1, 1.06 ± 0.092 h and 1755.02 ± 228.90 μg.h.mL-1 for test .. Read More»
  DOI: 10.4172/1948-593X.1000021

  Abstract PDF