Journal of Surgery

M Danciu

Publications

• Research Article
  Macrophage Quantification in Different Breast Tumor Compartments
  Author(s): Anca Haisan, T Petreus, Daniela Jitaru, M Danciu and E CaraseviciAnca Haisan, T Petreus, Daniela Jitaru, M Danciu and E Carasevici
  
  Background and Aim: Breast cancer shows poor prognosis when tied with chronic inflammation mediated by tumor associated macrophages (TAM). However, TAM’s multiple role, localization and prognosis are still debatable. Our study aims to quantify macrophage area and compare defined tumor morphological compartments: tumor associated stroma (TAS), tumor parenchyma and invasive front. Material and Methods: Automated digital macrophage area quantification was standardized using a tissue cytometry system (TissueFAXS) on slides originated from 50 patients with invasive breast carcinoma. Macrophages were stained using immunohistochemistry with anti-CD68 marker. The three tumor compartments were manually delineated on the digital slides. Results:.. Read More»
  

  Abstract PDF