Egypt
Research Article
Interleukin-8 as a Surrogate Marker in Risk Stratification of Patients with Acute Myeloid Leukemia
Author(s): Mohammed Abdul Wahid Almorish, Waiel Mohmed Abdo Al-Kahiry, Maha Abubakr Feissal Rabie and Enas Ali Mohamed DammagMohammed Abdul Wahid Almorish, Waiel Mohmed Abdo Al-Kahiry, Maha Abubakr Feissal Rabie and Enas Ali Mohamed Dammag
Introduction: When molecular and cytogenetic studies are not available, the risk stratification of AML patients will be difficult. This study was conducted to evaluate the prognostic value of IL-8 among AML patients with its relation to outcome.
Methods: This is a cross sectional study; 42 newly diagnosed AML patients (<65 years) were investigated with determination of serum IL-8 by ELISA and followed up for 36 months. In addition, 20 sex and age matched normal volunteers were included as control.
Results: In AML patients, serum IL-8 was ranging from 5 to 200 pg/mL with a mean of 76.5 pg/mL. It was significantly higher among AML patients when compared to the control (76.5 vs 32.3 pg/mL). The mean did not show any significant relationship to patients’ sex or the FAB classification of AML (p>0.05). While .. Read More»
DOI:
10.37421/jbl.2019.9.240
Journal of Blood & Lymph received 443 citations as per Google Scholar report