Cancer Science & Therapy

Mahesh Kandula

Publications

• Research Article
  Differences in Gene Expression Profiles between Human Breast Tissue and Peripheral Blood Samples for Breast Cancer Detection
  Author(s): Mahesh Kandula, Kalyana Kumar Ch, Ravi Kanth K, Laxmi Addala VV, Sudha Murthy and YS Ammi RajuMahesh Kandula, Kalyana Kumar Ch, Ravi Kanth K, Laxmi Addala VV, Sudha Murthy and YS Ammi Raju
  
  The purpose of this study is to check the similarities of differential gene expression of 11 genes in breast cancer tissue and blood samples from the same individual for early detection of breast cancer. We had investigated differential gene expression by qRT-PCR in 20 breast cancer patients’ tumoral tissues and corresponding blood sample. In our analysis BRCA2, HER-2, ER, PR, MET and BRAF mRNA levels were significantly over expressed in tumoral tissues. ER and PR mRNA levels were not detected in any of the peripheral blood samples, whereas KRAS and PTEN mRNA levels were not detected in any of the tumoral tissues. HER-2 (45%), EGFR (40%) and PI3KCA (30%). KRAS and PTEN mRNA levels were significantly over expressed in peripheral blood. In the correlation analysis expression of.. Read More»
  DOI: 10.4172/1948-5956.1000171

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