Journal of Cytology & Histology

Mahlon D Johnson

Publications

• Research Article
  Identification of NKCC1 and Aquaporin 1 in Blood Vessels of Human Dura and Chronic Subdural Hematomas. A New Target for Bumetanide?
  Author(s): Mahlon D Johnson, Mary J O’Connell and Jason H HuangMahlon D Johnson, Mary J O’Connell and Jason H Huang
  
  Chronic Subdural Hematoma (CSH) may be challenging to manage due to neurological complications and frequent recurrence. The pathophysiology of fluid collection in CSHs is incompletely understood and the role of water and cation cotransporters in the movement of fluid from dural capillary/venous complexes into the dural border zone and hematomas is unknown. In the present study, normal dura was collected at autopsy from 9 fetal, 6 neonatal or infant, 11 adult and 16 aged patients. CSHs were collected from 15 surgical specimens. Na-K-2Cl cotransporter (NKCC1) and aquaporin 1 (AQP1) were evaluated using immunohistochemistry. In the normal dura, NKCC1 immunoreactivity was extensive in neonatal, infant and adult capillaries. NKCC1 was not detected in arterioles and large venules in the fetal and adult dura or in unlined channels at any age. AQP1 was extensiv.. Read More»
  DOI: 10.4172/2157-7099.1000191

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