Journal of Bioanalysis & Biomedicine

Mahmood Ahmad

Publications

• Research Article
  In-Vitro Release and Pharmacokinetics of Anti-tubercle Drug Ethionamide in Healthy Male Subjects
  Author(s): Mahmood AhmadMahmood Ahmad
  
  The aim of study was to assess the pharmacokinetics of ethionamide in the local population of healthy huma n sub- jects. Serum samples were taken from each of the selected subject at different time intervals. These samples were analyzed by using High Performance Liquid Chromatog - raphy consisting of reverse phase C18 column, UV de tec- tor set at 291nm. The mobile phase was consisted of 0.02 M disodium hydrogen phosphate and acetonitrile (75: 25) and delivered at a rate of 1.5ml/min. The value of C max was found to be 1.941 ± 1.487 μ g/ml (mean ± SEM) and T max was 1.75 ± 1.487 hours (mean ± SEM). The area un- der the curve (AUC) was 8.745 ± 0.536 (mean ± SEM). The elimination half life (t ½ ) was found out as 1.995 ± 1.157 hours (mean ± SEM). The total body clearance (Cl) was det.. Read More»
  DOI: 10.4172/1948-593X.1000010

  Abstract PDF